Malaysian Applied Biology Journal

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48_04_15

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Malays. Appl. Biol. (2019) 48(4): 115–120

 

DEVELOPMENT AND EVALUATION OF STABILITY OF GEL

FORMULATION CONTAINING Ageratum conyzoides EXTRACT


SIRIKUNYA SAYOMPARK*, SOPITA TANGPIRIYAVAREE, YUPA KHONGPRIK

and KHANITTA MEEPRADIT


Thai Traditional Medicine College, Rajamangala University of Technology Thanyaburi,

Thanyaburi, Pathum Thani, Thailand

*E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


Accepted 14 October 2019, Published online 30 November 2019

 

ABSTRACT

Ageratum conyzoides or ‘Billy Goat Weed’ is a weed distributed in many tropical and subtropical countries. It is widely utilized in traditional medicine by various cultures worldwide. The leaf, stem, root and flower of A. conyzoides was used to evaluate its chemical profile. Their extract exhibit a wide range of biological and pharmacological activities such as anti-inflammatory, anti-allergic, analgesic, antifungal, and anti-bacterial activities have been recorded. The objectives of the study were to evaluate the phytochemical screening tests of ethanolic extract of A. conyzoides and finally, the A. conyzoides extract was developed in Gel formulation. The A. conyzoides gel formulation was studied the stability at 45°C and heating/cooling condition, and then its appearance, viscosity, and pH value were determined. The presence phytochemical components of A. conyzoides extract include alkaloids, tannins, flavonoids and phenols. The AC-6 formulation was showed good physical properties: appearance, viscosity, and pH value by comparing it with marketed Diclofenac gel. The further study should be evaluated for anti-inflammatory and analgesic potency by animal paradigms, which may be helpful in developing novel new drugs.


Key words: Ageratum conyzoides, phytochemical screening, traditional medicine, gel formulation development

 

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Vol 48(4) November 2019

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