Malaysian Applied Biology Journal

  • Increase font size
  • Default font size
  • Decrease font size

48_03_02

E-mail Print PDF

Malays. Appl. Biol. (2019) 48(3): 11–17

 

CURATIVE POTENTIAL OF Zingiber zerumbet ON

PARACETAMOL-INDUCED HEPATOTOXICITY


NURSIRHAN ATHIRAH SHARKAWI, NUR HILWANI ISMAIL*, NURUL HUSNA MD JANI,

DZULSUHAIMI DAUD, NOORAAIN HASHIM, AZANI SALLEH and HARITA HASHIM


School of Biology, Faculty of Applied Sciences,

Universiti Teknologi MARA, 40450 Shah Alam Selangor, Malaysia

*E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


Accepted 3 June 2019, Published online 30 June 2019


ABSTRACT

Zingiber zerumbet is a type of wild ginger known worldwide for its medicinal values. Its constituents found in the rhizome suggest potent antioxidant and anti-inflammatory activities. As such, this study investigated the possible curative effects of Zingiber zerumbet rhizome ethanolic extract (ZZ) on Paracetamol (PCM)-induced hepatotoxicity. The plant was obtained from Sendayan, Negeri Sembilan and had been identified by the Biodiversity Unit of Universiti Putra Malaysia (UPM), Malaysia. Its rhizomes were processed and extracted with 80% ethanol. The chemical profile of the extract was determined using Gas Chromatography-Mass Spectrometry (GC-MS) analysis, while hepatotoxic rats were treated orally with varied extract doses (250, 350, and 450 mg/kg bwt) for a week, and N-acetyl-L-cysteine (NAC) was used as reference drug. At the end of the treatment, sera samples were collected for liver function tests (LFTs). The chemical profile of the extract determined via GC-MS analysis revealed three major compounds that contributed to the bioactivity of the plant. Zerumbone had the highest component concentration (95%) in the extract for GC-MS study. Significant improvements in LFT parameters (alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST), and total protein (TP) levels) were also observed in groups that received 350 and 450 mg/kg bwt extract, wherein the 350 mg/kg bwt dose appeared to be the most effective dose that reduced liver enzyme markers in PCM-induced hepatotoxic rats. Overall, Z. zerumbet exhibited the most optimum hepatocurative potential in enhancing liver functions amidst PCM-induced hepatotoxic rats at 350 mg/kg bwt dose.

Key words: Zingiber zerumbet, paracetamol (PCM), hepatotoxicity, liver function test (LFT), zerumbone

 

Latest MABJ Issue

Vol 48(3) June 2019

Table of content

Latest news!

Malaysian Applied Biology is listed in the databases and indexed in Thomson Reuters Master Journal List, Myjurnal, Biosis, Zoological Records, UDLedge Life Science Index, CNKI, J-Gate and CABI.

Malaysian Applied Biology is indexed in Scopus since issue 41(1) 2012.

According to MyCite 2014 report, MABJ ranked 95 out of 142 Malaysian journals in terms of yearly impact factor.