Malaysian Applied Biology Journal

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47_05_26

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Malays. Appl. Biol. (2018) 47(5): 213–218

 

WOUND HEALING PROPERTIES IN SPRAGUE-DAWLEY RATS

OF MARINE ENDOPHYTIC FUNGI EXTRACTS


AQILAH, H.M., NORHAYATI, A.S. and SITI, A.A.*


Marine Pharmaceutical Research Group (MaReG)

Faculty of Pharmacy, 42300 Universiti Teknologi MARA, Puncak Alam, Selangor

*E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it .


Accepted 18 October 2018, Published online 30 November 2018


ABSTRACT

Marine endophytic fungi are known to be profilic source of potential bioactive compounds. The aim of the present study was to investigate wound healing properties of three endophytic fungi extracts (CN, MV and ED) isolated from different seaweeds Gracilaria arcuata Zanardini, Gracilaria coronopifolia J.Agard and Acantophora spicifera (M.Vohl) on second degree burn wound healing. Circular second degree burn wounds were created on the dorsal region of normal rats and treated with silver sulphadianze (SSD) as positive control and Tween 20 only as negative control. This study showed treatment with all extracts increased the rate of wound contraction as compared to control groups. CN extract (48%) was more effective than ED (45%), MV (41%) and SSD (40%) starting on the first day of wound contraction observation. Histopathological findings showed all the extracts enhanced epithelisation and tissue granulation significantly as compared to control group. We demonstrated for the first time in the present study that these marine endophytic fungi extracts showed faster healing on the second degree burn even when compared with SSD (positive control). Results suggest that CN, MV and ED marine endophytic fungi extracts tested in this study could be exploited as a potential source for wound dressing occlusion and tissue repairing.

Key words: Marine seaweed, marine endophytic fungi, wound healing

 

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