Malaysian Applied Biology Journal

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46_04_25

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Malays. Appl. Biol. (2017) 46(4): 207–216

SUB ACUTE ORAL TOXICITY SCREENING ON JELLYFISH

Lobonema smithi CONSUMPTION IN SPRAGUE DAWLEY RATS

 

SUVIK ASSAW1,3* and MOHD EFFENDY ABD WAHID2,3

 

1School of Marine and Environmental Sciences, Universiti Malaysia Terengganu,

21030 Kuala Nerus, Terengganu, Malaysia

2School of Fisheries and Aquaculture, Universiti Malaysia Terengganu,

21030 Kuala Nerus, Terengganu, Malaysia

3Institute of Marine Biotechnology, Universiti Malaysia Terengganu,

21030 Kuala Nerus, Terengganu, Malaysia


*Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

Accepted 22 November 2017, Published online 31 December 2017

 

ABSTRACT

Consumption of jellyfish has been reported to be effective in treating several illnesses and has been a unique delicacy in most of East Asia countries. However, toxicity effect of the jellyfish consumption has not been reported although it has been eaten for generations. The aim of this study is to evaluate the toxicity effects on the consumption of white jellyfish Lobonema smithi in rat model. Toxicity effects were evaluated according to Fixed Dose Procedure OECD guidelines 420 which include determination of 50% of lethal dose (LD50), changes in body and relative organs weight, differential leucocytes count and histopathological analysis of the liver and kidney. Twenty-four female Sprague Dawley rats (180-220 g) were used in the study and were orally treated with different dosage of freeze dried L. smithi powder (100, 500, 2000 mg/kg of body weight respectively) for 14 days. Half of the rats from each group (n=3) were euthanized on day 14 for sub-acute study to obtain relative organs weight, haematology and histopathological analysis. Another half of the animals from each groups (n=3) were kept for another 14 days without any treatment for delayed toxicity studies. There were, no lethality observed at all dosage given and the LD50 value was evaluated to be more than 2000 mg/kg of body weight. Furthermore, no significant (p>0.05) changes were observed in animal body and relative organs weight, differential leucocytes counts, food consumption and water intake in all treatment groups compared to untreated animal for both sub-acute and delayed toxicity study. Moreover, histology analysis on liver and kidney from sub-acute and delayed toxicity studies have confirmed safe consumption of the jellyfish. This study has clearly satiated the white type jellyfish consumption is safe and do not show adverse or delay toxicity effect on biological aspects of the host.

Key words: Seafood, jellyfish, toxicity effect, liver, kidney, histology

 

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