Malaysian Applied Biology Journal

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46_01_21

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Malays. Appl. Biol. (2017) 46(1): 147–152

 

Ficus  deltoidea  ETHANOLIC LEAVES EXTRACT IMPROVES

HORMONAL BALANCE AMONG LETROZOLE INDUCED

POLYCYSTIC OVARIAN SYNDROME (PCOS) RATS

NUR AJEERAH SUHAIMI*, NOORAAIN HASHIM and NURDIANA SAMSULRIZAL

School of Biological Sciences, Faculty of Applied Sciences, Universiti Teknologi MARA,
40450 Shah Alam, Selangor, Malaysia

*Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Accepted 31 January 2017, Published online 31 March 2017

 

ABSTRACT

The global prevalence of polycystic ovarian syndrome (PCOS) has reached epidemic proportion contributing to female infertility. The two phenotypes of PCOS, hyperandrogemia and hyperinsulinemia have gained much attention even the exact etiology of the syndrome remained unclear. In the present study, Ficus deltoidea was evaluated to elucidate the effects of its ethanolic leaves extract on several PCOS key hormones of female Sprague Dawley rats induced with letrozole (1.0 mg/kg bwt.). Experimental animals were divided into six groups (A, B, C, D, E and F). Five groups (B, C, D, E and F) were induced into PCOS using 1.0 mg/kg letrozole and the sixth group, Group A was the non PCOS normal control (NC). Groups of PCOS induced rats were treated with: saline (B, PC), 10 mg/kg bwt. clomiphene citrate (C, PCC), and Groups D, E and F were treated with 25, 125 and 250 mg/kg bwt. of F. deltoidea ethanolic leaves extracts, respectively, (PFD25, PFD125 and PFD250). Absence of estrus phase from rat reproductive cycle throughout the induction period (21 days) with significantly higher (p<0.05) testosterone level than NC rats were observed among PCOS induced groups manifested PCOS development in the studied animal model. Hormonal profiling at the end of treatment period revealed significant reduction (p<0.05) in testosterone, FSH and LH levels, but significant increase (p<0.05) in both progesterone and estrogen levels in extract treated groups compared with PC group. Meanwhile, insulin level was significantly reduced (p<0.05) with value 0.265±0.046 ng/mL in PFD125 group compared with that of PC rats (0.801±0.025 ng/mL) suggesting improved insulin sensitivity in the extract treated PCOS rats. In summary, these results indicate the potential use of F. deltoidea leaves in ameliorating PCOS associated risks, since it is capable of alleviating excess androgen and enhancing insulin sensitivity in letrozole-induced PCOS rats.

Key words: Serum hormones, estrous cycle, letrozole, polycystic ovarian syndrome, F. deltoidea, ethanolic leaves extract, infertility

 

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