Malaysian Applied Biology Journal

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Malays. Appl. Biol. (1999) 28(1&2): 125-130



School ofBioscience & Biotechnology, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia


The efficiency of an antitumor-styrylpyrone derivative (SPD) in lowering the cholesterol levels in serum and atherosclerotic lesions was studied using rats given an atherogenic diet containing rat chow and 15% ghee (butter fat) and force-fee cholesterol (1% dissolved in ghee oil) to induce hypercholesterolemic condition. Serum cholesterol levels were elevated and atherosclerotic lesions were observed in the thoracic aorta and abdominal aorta after 8 months. SPD dissolved in nigella saliva oil (lOmg/kg) was given to the rats for 4 weeks. The SPD-treated rats had lower serum cholesterol levels (90.216 + 8.281mg/dl) as compared to non-treated rats (107.146 + 8.199mg/dl) and control rats treated only with nigella saliva oil (133.079 ± 6.118mg/dl). The triacylglycerol level in serum was highest in non-treated rats (221.569 ± 12.431mg/dl), followed by rats treated only with nigella saliva oil (181.750 + 29.345mg/dl) and SPD-treated rats (174.126 ± 52.930mg/dl). The atherosclerotic lesions were observed in rats treated only with nigella saliva oil and non-treated rats while SPD-treated rats had clearer aorta.

Key words : Styrylpyrne derivative, atherosclerosis, cholesterol


Azimahtol Hawariah, L.P. and Stanslas, J. 1998. Antagonistic effects of styrylpyrone derivative (SPD) on 7, 12-dimethylbenzanthracene-induced rat mammary tumors. In vivo, 12: 403-410.

Azimahtol Hawariah, L.P., Stanslas, J. and Laily, D. 1998. Non-steroid receptor-mediated antiproliferative activity of styrylpyrone derivative in human breast cancer cell lines. Anticancer Research, 18: 1739-1744.

Bishop, S.P. Cardiovascular Research. The Laboratory Rat. Vol. II. Academic Press, Inc. 1980. 174pp.

Fowler, S.D., Mayer, E.P. and Greenspan, P. 1985. Foam cells and atherogenesis. Annals New York Academy of Sciences. 454: 79-90.

Greenspan, P., Hong Yu, Feiwen Mao and Gutman, R.L. 1997. Cholesterol deposition in macrophages: Foam cell formation mediated by cholesterol-enriched oxidized low density lipo-protein. Journal of Lipid Research. 38: 101-109.

Hammad, A.M., Siegel, H.S. and Marks, H.L. 1998. Total cholesterol, total triglycerides and cholesterol distribution among lipoproteins as predictors of atherosclerosis in selected lines of Japanese quail. Comp. Biochemistry Physiology. Vol. 119A, No. 2: 485-492.

Khachadurian, A.K. Role of cholesterol in atherosclerosis. 1990. In Advances In: Cholesterol Research. Esfahani, M. and Swaney, J.B. (eds.). The Telford Press, Inc. 383-387pp.

Love, R.R., Mamby, C.C. and Feyzi, J.M. 1993. Tamoxifen-induced decreases in total cholesterol with 2 weeks of treatment. Journal of the National Cancer Institute. Vol. 85. No. 16: 1344-1345.

Love, R.R., Wiebe, D.A., Newcomb, P.A.,Cameron, L., Leventhal, H., Jordan, C., Feyzi, J. and DeMets, D.L. 1991. Effects of tamoxifen on cardiovascular risk factors in postmenopausal women. Annals of Internal Medicine. 115: 860-864.

Lee, N. K., Kritchevsky, D and Pariza, M.W. 1994. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis. 108: 19-25.

McDonald, C.C. and Stewart, H.J. 1992. Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial, B. Med. J. 303: 435-437. In: Tamoxifen decreases serum cholesterol by inhibiting cholesterol synthesis. Gylling, H., Mantyla, E. and Miettinen, T.A. 1991. Atherosclerosis. 96: 245-247.

SAS Institute. 1991. SAS/STAT User's Guide. Release 6.03 ed. SAS Institute Inc., Cary, NC. 10228pp.

Stein, O., Dabach, Y., Hollander, G., Halperin, G., Thiery, J. and Stein, Y. 1996. Relative resistance of the hamster to aortic atherosclerosis in spite of prolonged vitamin E deficiency and dietary hypercholesterolemia. Putative effect of increased HDL?. Biochimia et Biophysica Acta. 1299: 216-222.

Vikhert, A.M. and Zhdanov, V.S. 1981. The Effects of Various Diseases On The Development of Atherosclerosis. Pergamon Press. 12pp.

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