Malaysian Applied Biology Journal

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28-1&2-23

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Malays. Appl. Biol. (1999) 28(1&2): 125-130

AN ANTITUMOR-STYRYLPYRONE DERIVATIVE (SPD) LOWERS SERUM CHOLESTEROL LEVELS AND ATHEROSCLEROTIC LESIONS IN HYPERCHOLESTEROLEMIC RATS

M.Y. SERI CHEMPAKA, L.P. AZIMAHTOL HAWARIAH*, A. S. HALIMAH, and M. S. HASIDAH

School ofBioscience & Biotechnology, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia

ABSTRACT

The efficiency of an antitumor-styrylpyrone derivative (SPD) in lowering the cholesterol levels in serum and atherosclerotic lesions was studied using rats given an atherogenic diet containing rat chow and 15% ghee (butter fat) and force-fee cholesterol (1% dissolved in ghee oil) to induce hypercholesterolemic condition. Serum cholesterol levels were elevated and atherosclerotic lesions were observed in the thoracic aorta and abdominal aorta after 8 months. SPD dissolved in nigella saliva oil (lOmg/kg) was given to the rats for 4 weeks. The SPD-treated rats had lower serum cholesterol levels (90.216 + 8.281mg/dl) as compared to non-treated rats (107.146 + 8.199mg/dl) and control rats treated only with nigella saliva oil (133.079 ± 6.118mg/dl). The triacylglycerol level in serum was highest in non-treated rats (221.569 ± 12.431mg/dl), followed by rats treated only with nigella saliva oil (181.750 + 29.345mg/dl) and SPD-treated rats (174.126 ± 52.930mg/dl). The atherosclerotic lesions were observed in rats treated only with nigella saliva oil and non-treated rats while SPD-treated rats had clearer aorta.


Key words : Styrylpyrne derivative, atherosclerosis, cholesterol

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